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[大学生论坛]:癫痫患者非自然死亡的风险

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小J 发表于 2019-1-4 09:46:11 | 显示全部楼层 |阅读模式
本帖最后由 小J 于 2019-1-4 09:51 编辑


People who receive a diagnosis ofepilepsy are 2 to 3 times more likely than the rest of the population to dieprematurely. The degree to which this relative riskis elevated varies by cause of death. Earlier research has focused onsudden unexpected death in epilepsy, with less attention paid to other causes.
癫痫病人比其他人有2-3倍过早死亡的可能,这种相对的死亡率与死亡原因相关。早期的研究专注于癫痫病人的意外死亡,对于其他死亡原因关注较少。

Arecent call for action identified the need to better understandcause-specific mortality risk, particularly for unnatural causes (ie,unintentional injury, suicide, homicide, and iatrogenesis), in people withepilepsy. Furthermore, the need for accurateidentification of epilepsy and cause of death has been emphasized inepidemiologic studies. Several secondary care–basedobservational studies have reported 2- to 5-fold increased risks of unnaturalmortality.
最近一项活动在呼吁,应该多关注在癫痫病人中的因病死亡的风险,尤其是非自然死亡(例如,意外伤害,自杀,他杀,和医源性死亡)。此外,在流行病学研究中也强调了准确识别癫痫和死因的必要性。基于观察的研究报告显示,一些二级护理使非自然死亡率增加了2-5倍。

Somestudies examined the risk by type of unintentional injury, one reported themethod of suicide in people with epilepsy, but none comprehensively reportedrisks across the full range of suicide and unintentional injury or poisoningtypes. Aprevious study of suicide that used the US National Violent Death ReportingSystem reported that antiepileptic drugs (AEDs) were used in just 6% ofintentional poisoning deaths in people with epilepsy. Thiscontrasts with a study of nonfatal self-poisoning in which AEDs were the mostcommonly used medication type (27%) in people with epilepsy.
有些研究是以非故意伤害的类型来探究这种风险,其中一个报告了癫痫病人自杀的方式,但没有一个报告是包含所有通过自杀、非故意性伤害或中毒的方式。之前的一项关于自杀的研究报告使用了美国国家暴力死亡报告系统,报告说,在癫痫患者中,有6%因使用抗癫痫药物(aed)的故意中毒死亡。这与一项非致命自体中毒的研究形成了鲜明对比,在这项研究中,AEDS是最常使用的药物。


We estimated the relative risks of thespecific causes of unnatural mortality in people with epilepsy vs a matchedcomparison cohort without epilepsy. We used 2 linked primary care–mortalitydatabases to accurately estimate risks of cause-specific unnatural mortality. We also examinedhow frequently specific types of medication were involved in medicationpoisoning deaths.
我们估计了癫痫患者非自然死亡的特定原因的相对风险,进行了与没有癫痫病的对比。我们将这两个联系起来:初级保健——死亡率数据库来准确地估计特定于死因的非自然死亡率的风险。我们还研究了特定类型的药物在药物中毒死亡中的频率。



From JAMANeurol. Published online April 9, 2018. doi:10.1001/jamaneurol.2018.0333



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