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[大学生论坛]:早期接触狗和农场动物与儿童患哮喘的风险之间的关系

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sosolian 发表于 2017-12-31 14:57:06 | 显示全部楼层 |阅读模式

Early Exposure to Dogs and Farm Animalsand the Risk of Childhood Asthma.
早期接触狗和农场动物与儿童患哮喘的风险之间的关系。
Abstract
IMPORTANCE:
重要性:
The associationbetween early exposure to animals and childhood asthma is not clear, andprevious studies have yielded contradictory results.
早期接触动物和儿童哮喘之间的关系尚不清楚,以前的研究取得了矛盾的结果。

OBJECTIVE:
目的:
To determinewhether exposure to dogs and farm animals confers a risk of asthma.
判定接触狗和农场动物对于患哮喘的风险是否有影响

DESIGN, SETTING ANDPARTICIPANTS:
设计,设置和参与者:
In a nationwidecohort study, the association between early exposure to dogs and farm animalsand the risk of asthma was evaluated andincluded all children born in Sweden from January 1, 2001, to December 31, 2010(N = 1,011,051), using registry data on dog and farm registration, asthma medication,diagnosis, and confounders for parents and their children.
在一项全国性的队列研究中,对于早期接触狗和农场动物和哮喘风险之间的联系进行了评价,包含所有从200111日到20101231日在瑞典出生的孩子,,(N = 1011051  ),使用注册表数据对狗和农场,哮喘用药,诊断,和父母与子女的混杂因素进行登记。
The associationwas assessed as the odds ratio (OR) for a current diagnosis of asthma at age 6 years forschool-aged children and as the hazard ratio (HR) for incident asthma at ages 1 to 5years for preschool-aged children. Data were analyzed from January 1, 2007, toSeptember 30, 2012.
这种联系由被诊断为哮喘的6岁学龄儿童的比值比(OR),以及学龄前儿童在15岁时发生哮喘的危险比(HR)来评定。数据分析从200711日到2012930日。

EXPOSURES:
接触:
Living with a dogor farm animal.
与狗或农场动物生活。

MAIN OUTCOMES AND MEASURES:
主要成果及措施:
Childhood asthma diagnosis andmedication used.
儿童哮喘的诊断与用药。

RESULTS:
结果:
Of the 1,011,051children born during the study period, 376,638 preschool-aged (53,460 [14.2%]exposed to dogs and 1729 [0.5%] exposed to farm animals) and 276,298school-aged children (22,629 [8.2%] exposed to dogs and 958 [0.3%] exposed tofarm animals) were included in the analyses.
分析包含在研究期间出生的1011051名儿童中,376638学龄前年龄儿童(其中53460 [ 14.2% ]接触于狗和1729 [ 0.5% ]接触于农场动物)和276298学龄儿童(其中22629 [ 8.2% ]接触于狗和958 [0.3%]解除与农场动物)
Of these, 18,799children (5.0%) in the preschool-aged children's cohort experienced anasthmatic event before baseline, and 28,511 cases of asthma and 906,071 yearsat risk were recorded during follow-up (incidence rate, 3.1 cases per 1000years at risk).
其中,学龄前儿童队列中18799名儿童(5%)在基线之前经历了哮喘事件,随访期间记录了28511例哮喘和906071年的风险(发病率为每1000年风险为1例)。
In the school-agedchildren's cohort, 11,585 children (4.2%) experienced an asthmatic event duringthe seventh year of life.
在学龄儿童的队列中,11585名儿童(4.2%)在生活的第七年患上了哮喘。
Dog exposureduring the first year of life was associated with a decreased risk of asthma in school-agedchildren (OR, 0.87; 95% CI, 0.81-0.93) and in preschool-aged children 3 yearsor older (HR, 0.90; 95% CI, 0.83-0.99) but not in children younger than 3 years(HR, 1.03; 95% CI, 1.00-1.07).
在生命的第一年接触狗是与降低哮喘的风险是相关的,在学龄儿童(或,0.8795% CI,量)和学龄前儿童3岁或以上(HR0.9095% CI0.83-0.99)是可行的,但在不小于3岁的儿童中是不可行的(HR1.0395% CI1.00-1.07)。
Results werecomparable when analyzing only first-born children.
结果只有在分析长子时有可比性。
Farm animalexposure was associated with a reduced risk of asthma in bothschool-aged children and preschool-aged children (OR, 0.48; 95% CI, 0.31-0.76,and HR, 0.69; 95% CI, 0.56-0.84), respectively.
接触农场动物与降低哮喘的风险相关,分别在在学龄儿童和学龄前儿童中可体现(OR0.4895% CI0.31-0.76HR0.6995% CI0.56-0.84)。

CONCLUSIONS AND RELEVANCE:
结论与相关性:
In this study, thedata support the hypothesis that exposure to dogs and farm animals during thefirst year of life reduces the risk of asthma in children at age6 years.
在这项研究中,数据支持这一假设:6岁的儿童在生命的第一年接触狗和农场动物可以降低患哮喘的风险。
This informationmight be helpful in decision making for families and physicians on theappropriateness and timing of early animal exposure.

这些信息可能有助于家庭和医生决定孩子早点接触动物的时机。

作者:Fall T1, Lundholm C2, Örtqvist AK2, Fall K3, Fang F2, Hedhammar Å4, Kämpe O5, Ingelsson E1, Almqvist C6.
期刊名称:JAMA Pediatr.
发表时间:2015Nov;169(11):e153219. doi: 10.1001/jamapediatrics.2015.3219. Epub 2015 Nov 2.

2014级医学英语 连静婷 3141201007



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