请选择 进入手机版 | 继续访问电脑版
设为首页收藏本站

老西部英语

 找回密码
 立即注册

只需一步,快速开始

[大学生论坛]:特发性震颤

13

主题

13

资源

52

积分

注册会员

Rank: 2

积分
52
Selene 发表于 2017-12-30 23:09:39 | 显示全部楼层 |阅读模式

特发性震颤

Idiopathic Tremor

特发性震颤(ET)是临床最常见的运动障碍性疾病,发病率约为5%,老年人群可升至20%;临床主要表现为姿势性或动作性震颤,部分可见头部或声音震颤。
既往研究显示,特发性震颤是一种功能性疾病,仅表现为震颤这一运动症状,被认为是一种进展缓慢、症状单一、良性运动障碍性疾病。然而,越来越多的研究显示,特发性震颤是一种累及多系统的疾病,包括运动症状如意向性震颤和共济失调,以及非运动症状(NMS)如认知功能障碍、情感障碍和听力下降等。
Idiopathic tremor (ET) is the most common clinical dyskinetic disease, the incidence of about 5%, the elderly can be increased to 20%. The main clinical manifestations are postural or motor tremors, and some of them present thrills or head tremors.
Previous studies have shown that idiopathic tremor is a functional disorder that manifests only as a motor symptom of tremor and is considered to be a slow-moving, single-symptom, benign dyskinetic disorder. However, an increasing number of studies have shown that idiopathic tremor is a multi-systemic disorder involving motor symptoms such as intentional tremor and ataxia, as well as non-motor symptoms (NMS) such as cognitive impairment, affective disorder and hearing loss .


此外,特发性震颤并非呈良性病程,Louis等的流行病学调查研究显示,特发性震颤患者病死率增加45%;Benito-León等对年龄≥65岁的特发性震颤患者随访3.30年发现其进展为帕金森病(PD)的概率增加4倍。本文拟就近年来特发性震颤病理学研究和发病机制、临床表现、影像学特点及治疗进展进行概述。
In addition, idiopathic tremor is not a benign course, epidemiological investigation of Louis  showed that patients with idiopathic tremor increased mortality by 45%; Benito-León followed up patients greater than or equal to 65 years old for 3.30 years .The probability of progressing to Parkinson's disease (PD) was found to increase fourfold.In this paper, we will summarize the research on pathogenesis of idiopathic tremor and its pathogenesis, clinical manifestations, imaging features and treatment progress in recent years.


特发性震颤的核心运动症状是上肢远端姿势性或动作性震颤,伴头部、口面部或声音震颤。流行病学调查研究显示,95%以上患者可累及上肢,其他部位依次为头部(30%以上)、声音(20%以上)、舌(20%)、面部和(或)下颌(10%)、下肢(10%)和躯干(5%)。
The core locomotor symptoms of idiopathic tremor are postural or behavioral tremor at the distal extremities with head, mouth, or tremor. Epidemiological studies have shown that more than 95% of the patients can be involved in the upper limbs, followed by head (30%), sound (20%), tongue (20%), face and / or mandible (10% , lower limbs (10%) and trunk (5%).


随着病程的延长,临床症状逐渐加重,至晚期可出现意向性震颤;部分表现为瞬目反射延迟或缺失;即使步态正常,仍可出现直线行走不稳。特发性震颤患者还表现出多种非运动症状,包括认知功能障碍、情感障碍和听力下降等,此外,还可以出现轻度认知损害(MCI)
With the extension of the course, clinical symptoms gradually worsened, to the terminal can appear intention tremor;part of the performance of blink reflex delay or loss; even if the abnormal gait, still can appear straight walking instability.Patients with idiopathic tremor also exhibit a variety of non-motor symptoms, including cognitive dysfunction, affective disorders, and hearing loss, as well as mild cognitive impairment (MCI)


本文来自:http://news.medlive.cn/neuro/info-progress/show-137311_100.html

友荐云推荐
评论

使用道具 举报


QQ|关于我们|联系我们|网络条款|建议反馈|小黑屋|老西部英语 ( 版权所有 粤ICP备11103350号  

GMT+8, 2018-9-19 00:14 , Processed in 0.173662 second(s), 37 queries .

Powered by Discuz! X3

© 2001-2013 Comsenz Inc.