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[大学生论坛]:长期较粗PM暴露与儿童哮喘相关!

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刘倩 发表于 2017-12-30 19:43:04 | 显示全部楼层 |阅读模式
长期较粗PM暴露与儿童哮喘相关!
Long term thicker PM exposure is associated with childhood asthma!


可入肺颗粒物(PM2.5)的短期和长期暴露与哮喘的发生、发展以及发病率有关,但长期暴露于较粗的PM(PM10-2.5)对呼吸健康影响的数据较少。近日,呼吸内科以及重症医学领域权威杂志Am J Resp Crit Care上发表了一篇研究文章,研究人员旨在理解儿童长期暴露于较细和较粗PM暴露与哮喘患病率和发病率之间的关系。
Short-term and long-term exposure to particulate matter (PM2.5) is associated with the occurrence, progression and incidence of asthma. However, there is less data about the impact of exposure to thicker PM (PM10-2.5) on respiratory health in long-term. Recently, a research article was published on Am J Resp Crit Care, an authoritative journal of respiratory medicine and critical care medicine. The purpose of this study is to understand the relationship between the long-term exposure to fine and coarse PM and the prevalence and incidence of asthma in children.


在这个半参数回归模型中,研究人员结合了PM2.5和PM10的监测数据以及地理特征来预测邮编制表地区2009-2010两年期间PM2.5和PM10的平均暴露水平。研究人员将从2009年至2010年期间收集的7810025名5-20岁的儿童参加了医疗补助的数据用于对数线性回归模型预测PM水平,来估计PM暴露与哮喘患病率和发病率之间的相关性,在调整种族、性别、年龄、地区级城市、贫困、教育和不可测的空间混杂因素后。
In this semiparametric regression model, the researchers combined the monitoring data and geographical features of PM2.5 and PM10 to predict the average exposure level of PM2.5 and PM10 between 2009 and 2010 of the zip code production area. Researchers use log-linear regression model for the data collected from 2009 to 2010 about 7810025 children aged between 5 and 20 who receive medicaid, to predict the correlation between prevalence and incidence of asthma and PM exposure, in the adjustment of gender, age, race, region, city, poverty, education and unpredictable spatial confounding factors.


将较细的PM进行调整后,研究人员发现暴露于粗PM与哮喘的诊断率(粗PM水平增加1µg/m3的RR为1.006,95%可信区间为1.001-1.011)、住院率(RR为1.023,95%可信区间为1.003-1.042)和急诊(ED)就诊(RR为1.017,95%可信区间为1.001-1.033)增加相关。与较粗的PM相比,较细的PM暴露与哮喘患病率和发病率密切相关。将不同程度的空间混杂因素进行调整后,估计值仍然升高。
After adjusting finer PM, the researchers found that exposure to crude PM is associated with the increase of asthma’s diagnosis rate (the crudeness of PM increases 1µg/m3, RR=1.006, 95% CI, 1.001-1.011), hospitalization rate (RR = 1.023, 95% CI, 1.003-1.042) and emergency (ED) treatment (RR = 1.017 95% CI, 1.001-1.033). Compared with coarser PM, finer PM exposure is closely related to the prevalence and incidence of asthma. After adjusting the different degree of spatial confounding factors, the estimated value still rises.


在接受医疗补助计划的儿童中,暴露于较高水平的粗PM与哮喘患病率和发病率增加有关。这些结果表明,需要直接监测粗PM,并且重新审议长期平均较粗PM污染水平的限制标准。
Among children receiving Medicaid, exposure to thicker PM is associated with an increase in the prevalence and incidence of asthma. These results indicate that a direct monitoring of coarse PM is needed and the criteria for long-term thicker PM pollution should be reviewed.


本文来自:http://www.medlive.cn/



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