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[大学生论坛]:男女不平等,压力大时女性更易受伤

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fee. 发表于 2017-12-30 17:49:39 | 显示全部楼层 |阅读模式
本帖最后由 fee. 于 2017-12-30 17:49 编辑

男女不平等,压力大时女性更易受伤
Gender inequality: females are more susceptible to heart disease when feeling stressed



心理应激性缺血机制和预后研究(MIPS)的最新数据显示,男性和女性冠心病患者发生心理应激性心肌缺血(MSIMI)时的心血管反应并不相同。
The latest data of mental stress ischemia prognosis study(MIPS) suggests that the cardiovascular response of male and female coronary artery disease(CAD) patients with mental stress-induced myocardial ischemia (MSIMI) is not the same.

研究表明,女性在有心理压力时主要表现为外周血管收缩,而男性则表现为血流动力学反应。该研究于2017年12月21日在线发表在《动脉硬化、血栓形成与血管生物学》杂志上。
Studies have shown that when psychological pressure comes, women mainly have peripheral vasoconstriction while men show hemodynamic responses. This research was reported online December 21st 2017 in the journal Arteriosclerosis, Thrombosis and Vascular Biology.


压力会引起交感神经系统激活,从而导致全身微血管收缩。数据显示,心理压力过大时,女性的微血管收缩更为严重,更可能发展为缺血。而在男性中,心理压力导致的缺血主要是由于血压和心率升高,从而血流动力学负荷增加。
Stress will activate the sympathetic nervous system, resulting in systemic microvascular contraction.Evidence show that microvascular constriction is more severe and more likely to develop into ischemia in women when it is overstressed; while for men, stress-induced ischemia is primarily due to increased blood pressure and heart rate , thereby increasing the hemodynamic load .


研究共纳入了492名男性和186名女性(平均年龄63岁)冠心病患者,每位患者都要接受公开演讲带来的心理压力测试,并在公开演讲前和过程中行心肌灌注显像,以评估心血管反应的性别差异,包括血流动力学反应以及与MSIMI有关的外周血管收缩。
Participants included 492 men and 186 women (mean age 63) with CAD, all patients will receive test of mental-stress brought by public speech , and apply myocardial perfusion imaging before and during the speech, to evaluate gender differences in cardiovascular responses, which includes hemodynamic responses and MSIMI-related peripheral vasoconstriction.


结果显示,有MSIMI的男性患者比无MSIMI的男性患者的心率收缩压乘积反应更高(6500 vs. 4800 mmHg bpm)。与无MSIMI的女性患者和有MSIMI的男性患者相比,有MSIMI的女性患者的外周动脉张力测定(PAT)比显著降低(分别为0.5 vs. 0.8,0.5 vs. 0.7)。而有MSIMI的男性患者的PAT比无显著差异(0.7 vs. 0.7)。
The results showed higher rate-pressure product (RPP) in men with MSIMI than that in men without MSIMI (6500 vs. 4800 mmHg bpm).Compared to women without MSIMI and men who with it, the ratio of peripheral arterial tension(PAT) of MSIMI women is significantly decreased (0.5 vs 0.8, 0.5 vs. 0.7 respectively).And there is no significant difference in PAT ratio of men with MSIMI.(0.7 vs. 0.7)


研究表明,两性在MSIMI的血流动力学和微血管机制方面存在着显著的性别差异。
This research suggested that there is a significant difference between the genders in hemodynamics and capillary mechanism of MSIMI.


虽然这些数据还没有改变临床实践,但是强调了心理压力下微循环对女性心肌缺血的巨大影响。另外,由于女性和男性在心血管生理学和缺血性心脏病病理生理学方面有所不同,需要将女性纳入心血管研究,并且要将女性和男性的数据单独计算。
Although these foundings have not changed clinical practice, it emphasized the strong impact of mental-stress on myocardial ischemia of females.Additionally, due to the difference of male and female in cardiovascular physiology as well as pathophysiology of ischemic heart disease, there is a need to include female in cardiovascular study and do the calculation respectively.


研究人员建议,目前在临床实践中并没有十分关注社会心理学领域,但是干预提醒心脏病患者减轻心理压力很重要,如果这些患者出现抑郁或焦虑,且需要帮助,应把他们推荐给相关专业人士。
Researchers suggest that it is important to remind cardiac patients to reduce mental stress, and they should be recommended to professionals if symptoms like depression or anxiety appeared.

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