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[大学生论坛]:哮喘

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trimy 发表于 2017-12-30 16:00:19 | 显示全部楼层 |阅读模式
Asthma
哮喘
Asthma—one of the most common chronic, non-communicable diseases in children and adults—is characterised by variable respiratory symptoms and variable airflow limitation.
哮喘是儿童和成人最常见的慢性非传染性疾病之一,其特点是多变的呼吸道症状和气流受限。
Asthma is a consequence of complex gene–environment interactions, with heterogeneity in clinical presentation and the type and intensity of airway inflammation and remodelling.
哮喘是复杂的基因-环境相互作用导致的,其临床表现具有异质性,包括不同类型和强度的气道炎症和重塑。
The goal of asthma treatment is to achieve good asthma control—ie, to minimise symptom burden and risk of exacerbations.
哮喘治疗的目的是实现良好的哮喘控制--即症状负荷和恶化风险的最小化。
Anti-inflammatory and bronchodilator treatments are the mainstay of asthma therapy and are used in a stepwise approach.
抗炎和支气管扩张剂(器)是治疗哮喘的主要方法手段,并得到循序渐进的使用。
Pharmacological treatment is based on a cycle of assessment and re-evaluation of symptom control, risk factors, comorbidities, side-effects, and patient satisfaction by means of shared decisions.
药物治疗会以一个周期的评估和重新评估为基础,其中包括通过共同决定的手段对症状控制、风险因素、合并症、副作用和病人的满意度进行的评估和重新评估。
Asthma is classed as severe when requiring high-intensity treatment to keep it under control, or if it remains uncontrolled despite treatment.
当需要高强度的治疗从而得以控制时,或当即使接受治疗也无法控制病情时,就会被归类为严重的哮喘。
New biological therapies for treatment of severe asthma, together with developments in biomarkers, present opportunities for phenotype-specific interventions and realisation of more personalised treatment.
治疗重症哮喘的新生物疗法和生物标志物的发展,为显型特异性干预和实现更个性化的治疗提供了机会。
In this Seminar, we provide a clinically focused overview of asthma, including epidemiology, pathophysiology, clinical diagnosis, asthma phenotypes, severe asthma, acute exacerbations, and clinical management of disease in adults and children older than 5 years.
在本次研讨会上,我们提供了一个临床集中的哮喘概述,其中包括流行病学、病理生理学、临床诊断、哮喘表型、严重哮喘、急性加重和对成人及5岁以上儿童的疾病临床管理。
Emerging therapies, controversies, and uncertainties in asthma management are also discussed.
同时我们也将针对新兴疗法、各种争论,和哮喘治疗中的不确定性进行讨论。


期刊名称:Lancet
发表时间:2017.12.19

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